Molecular biology of glutathione transferases
نویسنده
چکیده
immunochemically detectable protein, and catalytic activity in different liver samples (Distlerath et al., 1985; Shimada et al., 1986; Umbenhauer et al., 1986). However, rat P-450,,,., , the orthologue of P-450,,, and its activities are well correlated with levels of the 2000 nucleotide mRNA(s) coding for the protein (Churchill et al., 1987); this regulatory model does not seem appropriate for humans. As an alternative to variation in mRNA levels, P-450related activities may be altered by modifications of structural genes. We are presently examining genomic DNA samples from phenotyped individuals with cDNA and RNA probes to determine if any altered patterns can be related to unusual catalytic activity.
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تاریخ انتشار 2009